PIM-IN-2

Names

[ CAS No. ]:
1006699-45-1

[ Name ]:
PIM-IN-2

Biological Activity

[Description]:

PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC50 = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> Pim

[Target]

PIM2


[References]

[1]. Qian K, et al. Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode [J]. Journal of medicinal chemistry, 2009, 52(7): 1814-1827.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H22N4O2

[ Molecular Weight ]:
338.40

Related Compounds