CH5132799
Names
[ CAS No. ]:
1007207-67-1
[ Name ]:
CH5132799
[Synonym ]:
cc-614
2-Pyrimidinamine, 5-[6,7-dihydro-7-(methylsulfonyl)-2-(4-morpholinyl)-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-
5-(7-methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine
5-[7-(Methylsulfonyl)-2-(4-morpholinyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-pyrimidinamine
5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine
QCR-47
CH5132799
Biological Activity
[Description]:
[Related Catalog]:
[Target]
PI3Kα:14 nM (IC50)
PI3Kα-H1047R:5.6 nM (IC50)
PI3Kα-E545K:6.7 nM (IC50)
PI3Kα-E542K:6.7 nM (IC50)
PI3Kγ:36 nM (IC50)
PI3Kβ:120 nM (IC50)
PI3Kδ:500 nM (IC50)
PI3KC2β:5.3 μM (IC50)
mTOR:1.6 μM (IC50)
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
751.1±70.0 °C at 760 mmHg
[ Molecular Formula ]:
C15H19N7O3S
[ Molecular Weight ]:
377.422
[ Flash Point ]:
408.1±35.7 °C
[ Exact Mass ]:
377.127014
[ PSA ]:
136.54000
[ LogP ]:
-0.87
[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C
[ Index of Refraction ]:
1.706
[ Storage condition ]:
-20℃
Safety Information
[ Hazard Codes ]:
Xi