SPI009

Names

[ Name ]:
SPI009

[Synonym ]:
1-{[2-(2,4-Dichlorophenyl)ethyl]amino}-3-phenoxy-2-propanol
MFCD05261333
2-Propanol, 1-[[2-(2,4-dichlorophenyl)ethyl]amino]-3-phenoxy-

Biological Activity

[Description]:

SPI009 is a novel antipersister compound active against P. aeruginosa; reduces the number of persisters up to 100,000-fold in both lab strains and clinical isolates of P. aeruginosa when combined with distinct classes of antibiotics; efficiently kills persister cells with minor cytotoxicity, and causes no erythrocyte damage.

[References]

References 1. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00836-17. 2. Defraine V, et al. Front Microbiol. 2017 Dec 22;8:2585. View Related Products by Target Bacterial

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
494.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₉Cl₂NO₂

[ Molecular Weight ]:
340.244

[ Flash Point ]:
253.0±28.7 °C

[ Exact Mass ]:
339.079285

[ LogP ]:
4.38

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.586