ethyl 6-(4-bromophenyl)-3-(4-methoxy-4-oxobutyl)-4-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate

Names

[ Name ]:
ethyl 6-(4-bromophenyl)-3-(4-methoxy-4-oxobutyl)-4-methyl-2-oxo-1,6-dihydropyrimidine-5-carboxylate

[Synonym ]:
4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester
SW02

Biological Activity

[Description]:

SW02 is a potent activator of ATPase activity of Hsp70, with an EC50 of 150 μM. SW02 leads to accumulation of both total tau and phosphorylated tau (pTau)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

EC50: 150 ± 21 μM (ATPase activity of Hsp70)[1]

[References]

[1]. Jinwal UK, et al. Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci. 2009 Sep 30;29(39):12079-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₃BrN₂O₅

[ Molecular Weight ]:
439.30000

[ Exact Mass ]:
438.07900

[ PSA ]:
88.43000

[ LogP ]:
2.88360

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII