MCI-INI-3
Names
[ CAS No. ]:
1011366-31-6
[ Name ]:
MCI-INI-3
Biological Activity
[Description]:
MCI-INI-3 is a potent, selective, competitive inhibitor of ALDH1A3 (Ki=0.55 uM), shows poor inhibitory effect on the structurally related isoform ALDH1A1 (>140-fold selectivity).MCI-INI-3 also displays on inhibition against six isoforms of ALDH (ALDH16A1, ALDH7A1, ALDH9A1, ALDH2, ALDH1B1, ALDH18A1).MCI-INI-3 demonstrates selective binding to ALDH1A3 in glioma stem cell lysates, inhibits ALDH activity and affects RA synthesis in cells.
[References]
1. Jianfeng Li, et al. Commun Biol. 2021 Dec 21;4(1):1420.
Chemical & Physical Properties
[ Molecular Formula ]:
C21H15N3O4
[ Molecular Weight ]:
373.368