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PPARα activator compound 3

Names

[ CAS No. ]:
1011399-77-1

[ Name ]:
PPARα activator compound 3

[Synonym ]:
6-Cyclopropyl-1-(4-fluorophenyl)-3-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
MFCD09473550
1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 6-cyclopropyl-1-(4-fluorophenyl)-3-(1-methylethyl)-

Biological Activity

[Description]:

PPARα activator compound 3 is a specific PPAR activator that selectively up-regulates PPARα transcriptional activity, leading to PPARα target gene expression both in vitro and in vivo; reduces plasma triglyceride levels with similar efficiency as fenofibrate in high fructose-fed rats.

[References]

References 1. Tachibana K, et al. J Biol Chem. 2018 May 15. pii: jbc.RA118.002077. View Related Products by Target PPAR

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
452.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H18FN3O2

[ Molecular Weight ]:
339.363

[ Flash Point ]:
227.6±28.7 °C

[ Exact Mass ]:
339.138306

[ LogP ]:
4.98

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.684

Related Compounds