MK-3577

Names

[ CAS No. ]:
1019112-29-8

[ Name ]:
MK-3577

[Synonym ]:
β-Alanine, N-[4-[(1S)-1-[(R)-(4-chlorophenyl)(7-fluoro-5-methyl-1H-indol-3-yl)methyl]butyl]benzoyl]-
MK-3577
N-{4-[(1R,2S)-1-(4-Chlorophenyl)-1-(7-fluoro-5-methyl-1H-indol-3-yl)-2-pentanyl]benzoyl}-β-alanine

Biological Activity

[Description]:

A potent, oral active glucagon receptor antagonist blocking the glucagon effect for the treatment of T2DM; inhibits glucagon-mediated cAMP increases in CHO cells expressing the human glucagon receptor with IC50 of 8.3 nM. Diabetes Phase 2 Discontinued

[References]

References 1. Peng JZ, et al. AAPS J. 2014 Nov;16(6):1259-70. View Related Products by Target Glucagon Receptor Diabetes

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
702.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₀ClFN₂O₃

[ Molecular Weight ]:
521.022

[ Flash Point ]:
378.6±32.9 °C

[ Exact Mass ]:
520.192871

[ LogP ]:
7.03

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.626

MK-3577

Names

Biological Activity

Chemical & Physical Properties

Related Compounds