iST2-1

Names

[ CAS No. ]:
1019158-02-1

[ Name ]:
iST2-1

[Synonym ]:
2-(4-Methoxyphenyl)-1-{[5-(2-nitrophenyl)-2-furyl]methyl}pyrrolidine
Pyrrolidine, 2-(4-methoxyphenyl)-1-[[5-(2-nitrophenyl)-2-furanyl]methyl]-
MFCD14826567

Biological Activity

[Description]:

iST2-1 is a first-in-class, in vivo active ST2 (suppression of tumorigenicity 2) inhibitor with IC50 of 56.14 and 54.62 uM in AlphaLISA and the HEK-Blue IL-33 assay, respectively; decrease IFN-γ-producing T cell populations in the in vitro mixed lymphocyte reaction assays, reduces plasma sST2 levels, alleviate GVHD, and improve survival in vivo, ameliorates GVHD burden and maintains GVL effect in the murine MLL-AF9 leukemia model.

[References]

References 1. Ramadan AM, et al. JCI Insight. 2018 Jul 25;3(14). pii: 99208. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
500.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₂N₂O₄

[ Molecular Weight ]:
378.421

[ Flash Point ]:
256.5±30.1 °C

[ Exact Mass ]:
378.157959

[ LogP ]:
4.04

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.607

[ Storage condition ]:
2-8°C

iST2-1

Names

Biological Activity

Chemical & Physical Properties

Related Compounds