RO 5073012

A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors; restores the psychostimulant effects of amphetamine on locomotion in Taar1 transgenic mice, exhibits good pharmacokinetic profile after oral administration in rodents and is active in a CNS behavioural models.

References 1. Galley G, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5244-8. 2. Revel FG, et al. Neuropsychopharmacology. 2012 Nov;37(12):2580-92. View Related Products by Target Trace Amine-associated Receptor (TAAR)