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2'-Chloro-2'-deoxycytidine

Names

[ CAS No. ]:
10212-19-8

[ Name ]:
2'-Chloro-2'-deoxycytidine

[Synonym ]:
Cytidine,2'-chloro-2'-deoxy-(8CI,9CI)
2'-Chlor-2'-deoxycytidin
2'-Chloro-2'-deoxycytidine
2'-Chlor-2'-desoxy-cytidin
Cytidine, 2'-chloro-2'-deoxy-
2'-chloro-2'-deoxy-cytidine
2'-Deoxy-2'-chlorocytidine

Biological Activity

[Description]:

2-Chloro-2'-deoxycytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.  

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
551.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H12ClN3O4

[ Molecular Weight ]:
261.66

[ Flash Point ]:
287.2±32.9 °C

[ Exact Mass ]:
261.051636

[ PSA ]:
110.60000

[ LogP ]:
-1.43

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.736

Related Compounds