2-(1,3-benzodioxol-5-yl)-3-[3-(2-methylpropylamino)propyl]-1,3-thiazolidin-4-one,hydrochloride
Names
[ CAS No. ]:
102612-94-2
[ Name ]:
2-(1,3-benzodioxol-5-yl)-3-[3-(2-methylpropylamino)propyl]-1,3-thiazolidin-4-one,hydrochloride
[Synonym ]:
2-Benzo[1,3]dioxol-5-yl-3-(3-isobutylamino-propyl)-thiazolidin-4-on,Hydrochlorid
4-Thiazolidinone,3-(3-(isobutylamino)propyl)-2-(3,4-methylenedioxyphenyl)-,monohydrochloride
2-(1,3-benzodioxol-5-yl)-3-[3-(2-methylpropylamino)propyl]-1,3-thiazolidin-4-one hydrochloride
WIN 2661
2-benzo[1,3]dioxol-5-yl-3-(3-isobutylamino-propyl)-thiazolidin-4-one,hydrochloride
3-(3-(Isobutylamino)propyl)-2-(3,4-methylenedioxyphenyl)-4-thiazolidinone hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
517.5ºC at 760mmHg
[ Molecular Formula ]:
C17H25ClN2O3S
[ Molecular Weight ]:
372.91000
[ Flash Point ]:
266.8ºC
[ Exact Mass ]:
372.12700
[ PSA ]:
76.10000
[ LogP ]:
3.75580
[ Vapour Pressure ]:
8.15E-11mmHg at 25°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XJ6277000
- CHEMICAL NAME :
- 4-Thiazolidinone, 3-(3-(isobutylamino)propyl)-2-(3,4-methylenedioxyphen yl)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 102612-94-2
- LAST UPDATED :
- 198609
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C17-H24-N2-O3-S.Cl-H
- MOLECULAR WEIGHT :
- 372.95
- WISWESSER LINE NOTATION :
- T56 BO DO CHJ H- ET5NV DSTJ A3M1Y1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,132,1951 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,132,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 123,269,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 40,132,1951