2-Cyanoethyltetraisopropylphosphorodiamidite

Names

[ Name ]:
2-Cyanoethyltetraisopropylphosphorodiamidite

[Synonym ]:
3-bis[di(propan-2-yl)amino]phosphanyloxypropanenitrile
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
2-cyanoethyl N,N,N',N'-tetrapropan-2-ylphosphorodiamidoite
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidoite
2-Cyanoethyl N,N,N,N-tetraisopropylphosphordiamidite
2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite
Phosphorodiamidous acid, N,N,N',N'-tetrakis(1-methylethyl)-, 2-cyanoethyl ester
Phosphorodiamidous acid, tetrakis(1-methylethyl)-, 2-cyanoethyl ester
Bis(diisopropylamino)(2-cyanoethoxy)phosphine
MFCD00012213
2-Cyanoethyl N,N,N',N'-tetraisopropyldiamidophosphite
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphordiamidite
3-((Bis(diisopropylamino)phosphino)oxy)propanenitrile
2-Cyanoethyltetraisopropylphosphorodiamidite
2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphorodiamidite

Chemical & Physical Properties

[ Density]:
0.949 g/mL at 25 °C(lit.)

[ Boiling Point ]:
298.1±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₃₂N₃OP

[ Molecular Weight ]:
301.408

[ Flash Point ]:
177.9±28.4 °C

[ Exact Mass ]:
301.228302

[ PSA ]:
53.09000

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.470(lit.)

[ Storage condition ]:
2-8°C

[ Stability ]:
Explodes When Heated

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H315-H317-H319-H334

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R5;R36/37/38

[ Safety Phrases ]:
S3-S26-S36

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
I

[ Hazard Class ]:
8

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity.

Nucleic Acids Res. 35(5) , 1441-51, (2007)

The synthesis of oligonucleotides containing 2'-deoxy-2'-fluoro-4'-thioarabinonucleotides is described. 2'-Deoxy-2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU) was incorporated into 18-mer antise...

DNA adducts of acrolein: site-specific synthesis of an oligodeoxynucleotide containing 6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one, an acrolein adduct of guanine.

Chem. Res. Toxicol. 15(5) , 607-13, (2002)

3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-6-hydroxy-5,6,7,8-tetrahydropyrimido[1,2-a]purin-10(3H)-one is formed in low yield by the reaction of acrolein with 2'-deoxyguanosine. The nucleoside and an o...

Synthesis and fluorescence studies of multiple labeled oligonucleotides containing dansyl fluorophore covalently attached at 2'-terminus of cytidine via carbamate linkage.

Bioconjug. Chem. 15 , 638-646, (2004)

Synthesis of modified oligonucleotides in which the specific cytidine nucleoside analogues linked at 2'-OH position via a carbamate bond with an amino ethyl derivative of dansyl fluorophore is reporte...