CMP-5 hydrochloride
Names
[ CAS No. ]:
1030021-40-9
[ Name ]:
CMP-5 hydrochloride
[Synonym ]:
9H-Carbazole-3-methanamine, 9-ethyl-N-(2-pyridinylmethyl)-, hydrochloride (1:1)
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-pyridinylmethyl)methanamine hydrochloride (1:1)
Biological Activity
[Description]:
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells; displays no activity against other type I (PRMT1 and PRMT4) and type II (PRMT7) enzymes; inhibition of PRMT5 leads to lost recruitment of a PRMT5/p65/HDAC3-repressive complex on the miR96 promoter, restored miR96 expression, and PRMT5 downregulation.
[References]
References 1. Alinari L, et al. Blood. 2015 Apr 16;125(16):2530-43. View Related Products by Target Histone Methyltransferase (HMTase)
Chemical & Physical Properties
[ Molecular Formula ]:
C21H22ClN3
[ Molecular Weight ]:
351.872
[ Exact Mass ]:
351.150238