THIODAN SULFATE

Names

[ Name ]:
THIODAN SULFATE

[Synonym ]:
MFCD00151179
(5aR,6R,9S,9aS)-6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3,3-dioxide
EINECS 200-659-6
(1R,2R,8S,9S)-1,9,10,11,12,12-Hexachloro-4,6-dioxa-5-thiatricyclo[7.2.1.0]dodec-10-ene 5,5-dioxide
THIODAN SULFATE
(1R,2R,8S,9S)-1,9,10,11,12,12-Hexachloro-4,6-dioxa-5-thiatricyclo[7.2.1.0]dodéc-10-ène-5,5-dioxyde
Endosulfan sulfate
6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro-, 3,3-dioxide, (5aR,6R,9S,9aS)-

Biological Activity

[Description]:

Endosulfan sulfate is the major metabolite of the insecticide Endosulfan, used for various crops. Endosulfan sulfate is more toxic and persistent than Endosulfan[1].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Endosulfan sulfate is the major metabolite of the insecticide Endosulfan, which is composed of two stereoisomers (α and β)[1].

[References]

[1]. Lee, H., et al. X-ray crystal structure of endosulfan sulfate. Appl Biol Chem 62, 57 (2019).

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
480.7±45.0 °C at 760 mmHg

[ Melting Point ]:
181ºC

[ Molecular Formula ]:
C₉H₆Cl₆O₄S

[ Molecular Weight ]:
422.924

[ Flash Point ]:
244.5±28.7 °C

[ Exact Mass ]:
419.811798

[ PSA ]:
60.98000

[ LogP ]:
4.30

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.638

[ Storage condition ]:
APPROX 4°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RB9150000

CHEMICAL NAME :: 5-Norbornene-2,3-dimethanol, 1,4,5,6,7,7-hexachloro-, cyclic sulfate

CAS REGISTRY NUMBER :: 1031-07-8

LAST UPDATED :: 199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB85-143766

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H400

[ Precautionary Statements ]:
P264-P273-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+,N,Xn,F,T

[ Risk Phrases ]:
R28;R50;R53

[ Safety Phrases ]:
S22;S24/25;S45

[ RIDADR ]:
UN 2761 6.1(a)/PG 2

[ RTECS ]:
RB9150000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

Click to get detail synthetic route

Articles

Distribution and uptake pathways of organochlorine pesticides in greenhouse and conventional vegetables.

Sci. Total Environ. 505 , 1142-7, (2014)

The application of greenhouse vegetable cultivation has dramatically expanded worldwide during the last several decades. However, little information is available on the distribution and uptake of pest...

Development of a more specific and accurate multiple reaction monitoring method based on GC-EI/MS/MS for simultaneously monitoring and determining 34 kinds of pesticides in Qianjinzhidai pills.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 983-984 , 47-54, (2015)

A rapid and accurate multi-residue method was developed for simultaneously monitoring and determining 34 kinds of pesticides by GC-EI/MS/MS, successfully applied in Qianjinzhidai pills. Precision, rep...