1-Aminocyclopentanemethanol

Names

[ Name ]:
1-Aminocyclopentanemethanol

[Synonym ]:
Cycloleucinol
Cyclopentanemethanol, 1-amino-
EINECS 233-697-7
MFCD00010491
(1-Aminocyclopentyl)methanol
1-Aminocyclopentanemethanol

Chemical & Physical Properties

[ Density]:
1.016±0.06 g/cm3

[ Boiling Point ]:
68-69 ºC (1 Torr)

[ Melting Point ]:
20ºC(lit.)

[ Molecular Formula ]:
C₆H₁₃NO

[ Molecular Weight ]:
115.174

[ Flash Point ]:
68.6±19.8 °C

[ Exact Mass ]:
115.099716

[ PSA ]:
46.25000

[ LogP ]:
-0.16

[ Vapour Pressure ]:
0.2±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.4899 (589.3 nm 20 ºC)

[ Water Solubility ]:
Freely soluble (306 g/L) (25 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY4620000

CHEMICAL NAME :: Cyclopentanemethanol, 1-amino-

CAS REGISTRY NUMBER :: 10316-79-7

BEILSTEIN REFERENCE NO. :: 2715363

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H13-N-O

MOLECULAR WEIGHT :: 115.20

WISWESSER LINE NOTATION :: L5TJ AZ A1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,136,1969

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GY4620000

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Methods for the synthesis of xanthine-derived polycyclic fused systems. Szymanska E, et al.

Heterocycl. Comm. 19(5) , 297-310, (2013)

Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.

J. Med. Chem. 50 , 2341, (2007)

1-isoquinolinylguanidines were previously disclosed as potent and selective inhibitors of urokinase-type plasminogen activator (uPA). Further investigation of this template has revealed that incorpora...

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.

J. Med. Chem. 49 , 4409, (2006)

Female sexual arousal disorder (FSAD) is a highly prevalent sexual disorder affecting up to 40% of women. We describe herein our efforts to identify a selective neutral endopeptidase (NEP) inhibitor a...