Estra-1,3,5(10)-trien-17-ol,3-methoxy-, (17b)-
Names
[ CAS No. ]:
1035-77-4
[ Name ]:
Estra-1,3,5(10)-trien-17-ol,3-methoxy-, (17b)-
[Synonym ]:
3-methoxyestra-1,3,5(10)-trien-17-|A-ol
EINECS 213-858-8
17beta-Estradiol 3-methyl ether
[3H]-3-Methoxyestradiol
Oestradiol 3-methyl ether
[14C]-3-Methoxyestradiol
3-Methoxyoestradiol
3-O-Methyl Estradiol
Estradiol 3-methyl ether
3-Methoxyestradiol
Estradiol-17beta-3-methyl ether
Chemical & Physical Properties
[ Density]:
1.109 g/cm3
[ Boiling Point ]:
428.8ºC at 760 mmHg
[ Molecular Formula ]:
C19H26O2
[ Molecular Weight ]:
286.40900
[ Flash Point ]:
187.9ºC
[ Exact Mass ]:
286.19300
[ PSA ]:
29.46000
[ LogP ]:
3.91220
[ Vapour Pressure ]:
4.07E-08mmHg at 25°C
[ Index of Refraction ]:
1.566
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG7732000
- CHEMICAL NAME :
- Estra-1,3,5(10)-trien-17-beta-ol, 3-methoxy-
- CAS REGISTRY NUMBER :
- 1035-77-4
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C19-H26-O2
- MOLECULAR WEIGHT :
- 286.45
- WISWESSER LINE NOTATION :
- L E5 B666TTT&J E1 FQ OO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2 mg/kg
- SEX/DURATION :
- male 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 49,193,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2500 ug/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Fertility - other measures of fertility
- REFERENCE :
- ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 49,193,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 132 ug/kg
- SEX/DURATION :
- female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 47,444,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 1050 ug/kg
- SEX/DURATION :
- female 3-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 47,444,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 3 mg/kg
- SEX/DURATION :
- female 1 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965