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ML-162

Names

[ CAS No. ]:
1035072-16-2

[ Name ]:
ML-162

[Synonym ]:
2-Chloro-N-(3-chloro-4-methoxyphenyl)-N-{2-oxo-2-[(2-phenylethyl)amino]-1-(2-thienyl)ethyl}acetamide
2-(3-chloro-N-(2-chloro-1-oxoethyl)-4-methoxyanilino)-N-(2-phenylethyl)-2-thiophen-2-ylacetamide
2-Thiopheneacetamide, α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-

Biological Activity

[Description]:

A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.

[References]

References 1. Weïwer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. 2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Ras

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
699.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H22CI2N2O3S

[ Molecular Weight ]:
477.403

[ Flash Point ]:
376.7±31.5 °C

[ Exact Mass ]:
476.072815

[ LogP ]:
4.00

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.630

Related Compounds