MK-4827 (R-enantiomer)
Names
[ CAS No. ]:
1038915-58-0
[ Name ]:
MK-4827 (R-enantiomer)
[Synonym ]:
2-{4-[(3R)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
MK-4827 (R-enantiomer)
Biological Activity
[Description]:
Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM.
[Related Catalog]:
[Target]
PARP-1:2.4 nM (IC50)
[In Vitro]
Niraparib R-enantiomer (MK-4827 R-enantiomer) resolution of Niraparib R-enantiomer give compounds Niraparib R-enantiomer and Niraparib S-enantiomer, both showing excellent inhibition of PARP-1. Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). Given this improved potency and similar in vitro turnover in human liver microsomes (HLM Clint, Niraparib R-enantiomer=4, Niraparib S-enantiomer=3 μL/min/mgP), Niraparib S-enantiomer (Niraparib) is focused on[1].
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H20N4O
[ Molecular Weight ]:
320.38800
[ Exact Mass ]:
320.16400
[ PSA ]:
72.94000
[ LogP ]:
3.62050