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CP-67804

Names

[ CAS No. ]:
103978-08-1

[ Name ]:
CP-67804

[Synonym ]:
3-Quinolinecarboxylic acid,1-ethyl-6,8-difluoro-1,4-dihydro-7-(4-hydroxyphenyl)-4-oxo
1-Ethyl-6,8-difluoro-7-(4-hydroxyphenyl)-4-quinolone-3-carboxylic acid
CP-67,804

Biological Activity

[Description]:

CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

Topoisomerase II


[In Vitro]

CP-67804 increases topoisomerase II-mediated DNA breakages by enhancing the enzyme's forward rate of cleavage[1].

[References]

[1]. Robinson MJ, et al. Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage. J Biol Chem. 1991;266(22):14585-14592.

Chemical & Physical Properties

[ Density]:
1.456g/cm3

[ Boiling Point ]:
526.5ºC at 760 mmHg

[ Molecular Formula ]:
C18H13F2NO4

[ Molecular Weight ]:
345.29700

[ Flash Point ]:
272.2ºC

[ Exact Mass ]:
345.08100

[ PSA ]:
79.53000

[ LogP ]:
3.37040

[ Vapour Pressure ]:
6.52E-12mmHg at 25°C

[ Index of Refraction ]:
1.623

Related Compounds