propamidine

Names

[ CAS No. ]:
104-32-5

[ Name ]:
propamidine

[Synonym ]:
4,4'-[Propane-1,3-diylbis(oxy)]dibenzenecarboximidamide
4,4'-[1,3-Propanediylbis(oxy)]bisbenzenecarboximidamide
DAPP
4,4'-[1,3-Propanediylbis(oxy)]dibenzenecarboximidamide
EINECS 203-195-2
m&b 782
4,4’-[propane-1,3-diylbis(oxy)]dibenzenecarboximidamide
α,ω-(4,4’-diamidinodiphenoxy)propane
4,4'-Diamidino-a,w-diphenoxypropane
Benzenecarboximidamide, 4,4'-[1,3-propanediylbis(oxy)]bis-
propamidine
Propamidine [BAN:DCF:INN]
4,4'-propanediyldioxy-bis-benzamidine
4,4’-(trimethylenedioxy)dibenzamidine
4,4'-Propandiyldioxy-bis-benzamidin
Brolene
4,4’-[1,3-propanediylbis(oxy)]bis[benzenecarboximidamide]

Biological Activity

[Description]:

Propamidine is a covalent inhibitor of TMPRSS2 and has some antibacterial activity.[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Amanda L. Peiffer, et al. TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform. bioRxiv [Preprint]. 2021 Mar 27:2021.03.22.436465.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
497.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₀N₄O₂

[ Molecular Weight ]:
312.37

[ Flash Point ]:
254.6±31.5 °C

[ Exact Mass ]:
312.158630

[ PSA ]:
118.20000

[ LogP ]:
1.62

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.608

Safety Information

[ HS Code ]:
2925290012

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290012

[ Summary ]:
2925290012 (e)-3-(((dimethylamino)methylene)amino)phenyl methylcarbamate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%