Eicosapentaenoic Acid

Names

[ Name ]:
Eicosapentaenoic Acid

[Synonym ]:
Eicosapentanoic acid
Ropufa 70
all-cis-5,8,11,14,17-Eicosapentaenoic Acid
Eicosapentaenoic acid, 5,8,11,14,17-(Z,Z,Z,Z,Z)-
5,8,11,14,17-Eicosapentaenoic acid, (5Z,8Z,11Z,14Z,17Z)-
eicosapentenoic acid
EICOSA-5Z,8Z,11Z,14Z,17Z-PENTAENOIC ACID (20:5, N-3)
ALL CIS-5,8,11,14,17-EICOSAPENTAENOIC ACID
icosapento
5C,8C,11C,14C,17C-EICOSAPENTAENOIC ACID
5,8,11,14,17-Icosapentaenoic Acid
92-PGM
(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Icosapentaenoic acid
5,8,11,14,17-EICOSAPENTAENOIC ACID (ALL-CIS)
(5Z,8Z,11Z,14Z,17Z)-Icosa-5,8,11,14,17-pentaenoic acid
Icosapentaenoic acid
PUFA 20:5n-3
ICOSAPENT
all-cis-5,8,11,14,17-icosapentaenoic acid
cis-5,8,11,14,17-Eicosapentaenoic acid
(5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid
Timnodonic acid
5,8,11,14,17-Eicosapentaenoic Acid
all-Z-eicosa-5,8,11,14,17-pentaenoic acid
EPA
acid 5
(5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid
(5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-Eicosapentaenoic acid
MFCD00065716
Eicosapentaenoic acid
CIS-5,8,11,14,17-EICOSAPENTAIENOIC ACID
all cis-5,8,11,14,17-Icosapentaenoic Acid

Biological Activity

[Description]:

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid.

[Related Catalog]:

Research Areas >> Neurological Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[References]

[1]. Martins, J.G., EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr, 2009. 28(5): p. 525-42.

[2]. Huan, M., et al., Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol Psychiatry, 2004. 56(7): p. 490-6.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
439.3±24.0 °C at 760 mmHg

[ Melting Point ]:
-54--53ºC(lit.)

[ Molecular Formula ]:
C₂₀H₃₀O₂

[ Molecular Weight ]:
302.451

[ Flash Point ]:
336.0±18.0 °C

[ Exact Mass ]:
302.224579

[ PSA ]:
37.30000

[ LogP ]:
6.23

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.513

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in methanol

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
26-36/37/39-45

[ RIDADR ]:
UN 3265

[ WGK Germany ]:
3

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2916190090

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

HMDB: a knowledgebase for the human metabolome.

Nucleic Acids Res. 37(Database issue) , D603-10, (2009)

The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, ...

The human serum metabolome.

PLoS ONE 6(2) , e16957, (2011)

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m...