Histatin-5

Names

[ Name ]:
Histatin-5

[Synonym ]:
DSHAKRHHGYKRKFHEKHHSHRGY
HISTATIN 5 (HUMAN)
L-Asp-L-Ser-L-His-L-Ala-L-Lys-L-Arg-L-His-L-His-Gly-L-Tyr-L-Lys-L-Arg-L-Lys-L-Phe-L-His-L-Glu-L-Lys-L-His-L-His-L-Ser-L-His-L-Arg-Gly-L-Tyr-OH
H-ASP-SER-HIS-ALA-LYS-ARG-HIS-HIS-GLY-TYR-LYS-ARG-LYS-PHE-HIS-GLU-LYS-HIS-HIS-SER-HIS-ARG-GLY-TYR-OH
ASP-SER-HIS-ALA-LYS-ARG-HIS-HIS-GLY-TYR-LYS-ARG-LYS-PHE-HIS-GLU-LYS-HIS-HIS-SER-HIS-ARG-GLY-TYR

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃₃H₁₉₅N₅₁O₃₃

[ Molecular Weight ]:
3036.29000

[ Exact Mass ]:
3034.51000

[ PSA ]:
1378.68000

[ LogP ]:
1.42620

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death.

J. Biol. Chem. 274 , 18872, (1999)

Salivary histatins are potent in vitro antifungal proteins and have promise as therapeutic agents against oral candidiasis. We performed pharmacological studies directed at understanding the biochemic...

Histatin 5 is a substrate and not an inhibitor of the Arg- and Lys-specific proteinases of Porphyromonas gingivalis.

Biochem. Biophys. Res. Commun. 250 , 474, (1998)

The salivary peptide histatin 5 has been reported to be an inhibitor of the Arg- and Lys-specific proteinases of Porphyromonas gingivalis, an oral pathogen associated with periodontitis. In this study...

Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis.

Biochem. Biophys. Res. Commun. 174 , 625, (1991)

We examined the effect of histatin 5 from human parotid saliva on various proteases. Histatin 5 strongly inhibited a trypsin-like protease produced by Bacteroides gingivalis with an IC50 value of 55 n...