Cinacalcet metabolite M4

Names

[ Name ]:
Cinacalcet metabolite M4

[Synonym ]:
3-[3-(Trifluoromethyl)phenyl]-1-propanamine
Benzenepropanamine, 3-(trifluoromethyl)-

Biological Activity

[Description]:

Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. Kumar GN, et al. Metabolism and disposition of calcimimetic agent cinacalcet HCl in humans and animalmodels. Drug Metab Dispos. 2004 Dec;32(12):1491-500.

[2]. Bushinsky DA, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
222.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₂F₃N

[ Molecular Weight ]:
203.204

[ Flash Point ]:
92.6±12.0 °C

[ Exact Mass ]:
203.092178

[ PSA ]:
26.02000

[ LogP ]:
2.40

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.468

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2921499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921499090

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%