Ethyl 3-oxoglutarate

Names

[ CAS No. ]:
105-50-0

[ Name ]:
Ethyl 3-oxoglutarate

[Synonym ]:
Diethyl acetone-1,3-dicarboxylate or 3-Oxo-pentanedioic acid, diethy ester
ETHYL ACETONEDICARBOXYLATE
Glutaric acid, 3-oxo-, diethyl ester
Ethyl 3-oxoglutarate
diethylacetone dicarboxylate
Pentanedioic acid, 3-oxo-, diethyl ester
DIETHYL 3-KETOGLUTARATE
DIETHYL 3-OXOGLUTARATE
Diethyl-3-oxopentaediote
Diethyl β-oxoglutarate
1,3-Acetonedicarboxylic Acid Diethyl Ester
3-Oxopentanedioic acid diethyl ester
Diethyl 3-oxopentanedioate
Glutaric acid, 3-oxo-, diethyl ester (8CI)
EINECS 203-302-2
3-oxoglutaric acid diethyl ester
Diethyl-3-oxo-pentan
Diethyl Acetone-1,3-Dicarboxylate
MFCD00009200

Biological Activity

[Description]:

Diethyl 3-oxopentanedioate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

1-取代的 4-乙氧基羰基-5-（乙氧基羰基甲基）吡唑的合成丙酮-1, 3-二甲酸二乙酯在室温下在乙醇中与 N, N-二甲基甲酰胺二甲基缩醛 (DMFDMA) 反应。意外的产品二分法是在 2-羟基苯甲醛与尿素或硫脲和丙酮-1,3-二甲酸二甲酯或二乙酯分别作为活性亚甲基组分的 Biginelli 样缩合中产生的。2-氨基-4-(2-乙氧基-2-氧代乙基)噻唑-5-甲酸乙酯 (2a)，由 1,3-二甲酸二乙酯、磺酰氯和硫脲制备。通过 3-chloro-3-oxo-2, 2-dimethylpropionate 与 diethyl acetone-1,3-dicarboxylate 的反应合成 diethyl 2,2-diethyl-3,5-dioxopimelate。

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
250.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₄O₅

[ Molecular Weight ]:
202.21

[ Flash Point ]:
86.1±0.0 °C

[ Exact Mass ]:
202.084122

[ PSA ]:
69.67000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.435

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
10 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F: Flammable;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
UN 2810

[ WGK Germany ]:
3

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Synthesis and antitumor cytotoxicity evaluation of pyrido[4,3,2-de]quinolines and isoquinolino[6,5,4,3-cde]quinolines.

Anticancer Drug Des. 15(2) , 99-108, (2000)

A series of novel pyrido[4,3,2-de]quinoline and isoquinolino[6,5,4,3-cde] quinoline compounds was synthesized and evaluated for cytotoxicity in the National Cancer Institute developmental therapeutics...

A synthesis of the pyrazomycins.

J. Org. Chem. 41(2) , 287-90, (1976)

A practical synthesis of (±)-thienamycin. Melillo DG, et al.

Tetrahedron Lett. 21(29) , 2783-86, (1980)