Mometasone

Names

[ Name ]:
Mometasone

[Synonym ]:
9a,21-dichloro-11b,17-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione
MFCD02683426
Pregna-1,4-diene-3,20-dione,9,21-dichloro-11,17-dihydroxy-16-methyl-,(11b,16a)-(9CI)
Mometasone
MOMETOSONE FUROATE

Biological Activity

[Description]:

Mometasone is an inhaled glucocorticoid. Mometasone can be used in mild asthma with a low sputum eosinophil level. Mometasone has the potential for the research of chronic hand eczema and rhinosinusitis[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vivo]

Mometasone (0.1-3 mg/kg; intranasally) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested of 3 mg/kg, and dose-dependently inhibits the allergen-induced increase in Penh in a mouse model of allergic lung inflammation[3].

[References]

[1]. Veien NK, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999 May;140(5):882-6.

[2]. Lazarus SC, et al. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 May 23;380(21):2009-2019.

[3]. Wyss D, et al. Synergistic effect of formoterol and mometasone in a mouse model of allergic lung inflammation. Br J Pharmacol. 2007 Sep;152(1):83-90.

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
586.6ºC at 760mmHg

[ Melting Point ]:
220ºC (decomposes)

[ Molecular Formula ]:
C₂₇H₃₀Cl₂O₆

[ Molecular Weight ]:
521.42900

[ Flash Point ]:
308.5ºC

[ Exact Mass ]:
520.14200

[ PSA ]:
93.81000

[ LogP ]:
4.86920

[ Vapour Pressure ]:
4.47E-18mmHg at 25°C

[ Index of Refraction ]:
1.603

Mometasone

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds