5-Chloroindole-2-carboxylic acid

Names

[ Name ]:
5-Chloroindole-2-carboxylic acid

[Synonym ]:
1H-Indole-2-carboxylic acid, 5-chloro-
5-Chloro-1H-indole-2-carboxylic acid
5-Chloroindole-2-carboxylic acid
MFCD00005613
EINECS 234-050-1

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
449.7±25.0 °C at 760 mmHg

[ Melting Point ]:
287 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₆ClNO₂

[ Molecular Weight ]:
195.602

[ Flash Point ]:
225.8±23.2 °C

[ Exact Mass ]:
195.008713

[ PSA ]:
53.09000

[ LogP ]:
3.09

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.728

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL5998400

CHEMICAL NAME :: 1H-Indole-2-carboxylic acid, 5-chloro-

CAS REGISTRY NUMBER :: 10517-21-2

BEILSTEIN REFERENCE NO. :: 0153229

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H6-Cl-N-O2

MOLECULAR WEIGHT :: 195.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,659,1972

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL5998400

[ HS Code ]:
29339990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.

Neurosci. Lett. 136(1) , 56-8, (1992)

The potency, specificity and reversibility of various presumed glycine site N-methyl-D-aspartate (NMDA) antagonists was studied on neonatal rat spinal cord using the grease gap technique. 5,7-Dichloro...