2-adamantaneamine hydrochloride

Names

[ Name ]:
2-adamantaneamine hydrochloride

[Synonym ]:
Adamantan-2-amine hydrochloride (1:1)
2-adamantaneamine hydrochloride
Tricyclo[3.3.1.1]decan-2-amine, hydrochloride (1:1)
MFCD00074743
2-Adamantanamine hydrochloride (1:1)
2-Aminoadamantane Hydrochloride
Adamantan-2-amine hydrochloride
EINECS 234-074-2
adamantan-2-amine,hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
226.1ºC at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₁₀H₁₈ClN

[ Molecular Weight ]:
187.710

[ Flash Point ]:
96.5ºC

[ Exact Mass ]:
187.112778

[ PSA ]:
26.02000

[ LogP ]:
3.27210

[ Vapour Pressure ]:
0.0831mmHg at 25°C

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU4375100

CHEMICAL NAME :: 2-Adamantanamine, hydrochloride

CAS REGISTRY NUMBER :: 10523-68-9

LAST UPDATED :: 198506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H17-N.Cl-H

MOLECULAR WEIGHT :: 187.74

WISWESSER LINE NOTATION :: L66 B6/B-H/DI A B- C 1B ITJ AZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - anticonvulsant

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 14,313,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S36/37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AU4375100

[ HS Code ]:
2921300090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity.

J. Antibiot. 62(1) , 37-41, (2009)

A novel way of chemical modification of the antibiotic olivomycin I at the 2'-keto group of the side chain of the aglycone moiety was developed. Reaction of olivomycin I with the carboxymethoxylamine ...

Simultaneous liquid chromatographic assay of amantadine and its four related compounds in phosphate-buffered saline using 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorescent derivatization reagent.

Biomed. Chromatogr. 20(5) , 423-8, (2006)

Simultaneous HPLC assay of 1-adamantanamine hydrochloride (amantadine) and its four related compounds [2-adamantanamine hydrochloride (2-ADA), 1-adamantanmethylamine (ADAMA), 1-(1-adamantyl)ethylamine...

[A quantitative pharmaco-electroencephalographic analysis of the action of bromantane].

Biull. Eksp. Biol. Med. 116(11) , 515-8, (1993)

The action of the new stimulant bromantane on spectra power EEG on Fourier of sensorimotor cortex, dorsal hippocamp and lateral hypothalamus of left and right hemispheres of brain of rat in free behav...