4-Bromo-2-fluorobenzonitrile

Names

[ Name ]:
4-Bromo-2-fluorobenzonitrile

[Synonym ]:
Benzonitrile, 4-bromo-2-fluoro-
BENZONITRILE,4-BROMO-2-FLUORO
4-Bromo-2-fluoro-benzonitrile
2-fluoro-4-bromobenzonitrile
1-bromo-4-cyano-3-fluoro-benzene
4-Bromo-2-fluorobenzonitrile
MFCD00143264
4-bromo-2-fluorobenzenecarbonitrile
4-cyano-3-fluoro-bromobenzene
NCR BF DE
4-cyano-3-fluoro-1-bromobenzene

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
231.8±20.0 °C at 760 mmHg

[ Melting Point ]:
69-72 °C

[ Molecular Formula ]:
C₇H₃BrFN

[ Molecular Weight ]:
200.008

[ Flash Point ]:
94.0±21.8 °C

[ Exact Mass ]:
198.943283

[ PSA ]:
23.79000

[ LogP ]:
2.26

[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.578

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S36/37/39-S26-S22-S36

[ RIDADR ]:
3439

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.

Bioorg. Med. Chem. 14(20) , 6832-46, (2006)

A series of heteroaryl-pyridine containing inhibitors of Akt are reported. The synthesis and structure-activity relationships are discussed, leading to the discovery of a indazole-pyridine analogue (K...

Application of aryloximes as solid-phase ketone linkers.

Org. Lett. 5(1) , 7-10, (2003)

In both solution and the solid phase, a variety of ketone oxime anions have been treated with 4-substituted-2-fluorobenzonitriles to give the corresponding nucleophilic aromatic substitution aryloxime...

Tetrahedron Lett. 37 , 2885, (1996)