Glycine Anhydride

Names

[ CAS No. ]:
106-57-0

[ Name ]:
Glycine Anhydride

[Synonym ]:
piperazine-2,5-dione
EINECS 203-411-5
Glycocoll Anhydride
Cyclodiglycine
2,5-Diketopiperazine
2,5-Pyrazinediol, 3,6-dihydro-
3,6-Dihydro-2,5-pyrazinediol
5-24-05-00294 (Beilstein Handbook Reference)
2,5-Piperazinedione
Glycine Anhydride
Diglycolyldiamide
MFCD00006009
a,g-Diacipiperazine
Cycloglycylglycine
2,5-Dioxopiperazine
Oxiracetam Impurity 2

Chemical & Physical Properties

[ Density]:
1.2±0.1g/cm3

[ Boiling Point ]:
573.7±43.0°C at 760 mmHg

[ Melting Point ]:
300°C

[ Molecular Formula ]:
C₄H₆N₂O₂

[ Molecular Weight ]:
114.103

[ Flash Point ]:
301.9±28.3°C

[ Exact Mass ]:
114.042931

[ PSA ]:
58.20000

[ LogP ]:
-2.93

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
2~8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6325250

CHEMICAL NAME :: 2,5-Piperazinedione

CAS REGISTRY NUMBER :: 106-57-0

BEILSTEIN REFERENCE NO. :: 0112112

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H6-N2-O2

MOLECULAR WEIGHT :: 114.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,227,1954

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TL6325250

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents.

Eur. J. Med. Chem. 83 , 236-44, (2014)

Non-protected 2,5-diketopiperazine derivatives have poor solubility thus with negative impact on their bioavailability. In the present study, twenty-one novel soluble mono-protected, and three non-pro...

Rational design and combinatorial evaluation of enzyme inhibitor scaffolds: identification of novel inhibitors of matrix metalloproteinases.

J. Med. Chem. 41(13) , 2194-200, (1998)

The discovery of a novel series of heterocyclic matrix metalloproteinase (MMPs) inhibitors is described. Published crystal structures of peptidyl hydroxamates bound to MMPs were the basis for the rati...

Diagnostic NH and OH vibrations for oxazolone and diketopiperazine structures: b2 from protonated triglycine.

J. Am. Soc. Mass Spectrom. 22 , 1197-1203, (2011)

We present infrared multiple photon dissociation (IRMPD) spectra in the hydrogen stretching region of the simplest b fragment, b(2) from protonated triglycine, contrasted to that of protonated cyclo(G...