Glycidyl methacrylate
Names
[ CAS No. ]:
106-91-2
[ Name ]:
Glycidyl methacrylate
[Synonym ]:
Glycidyl Methacrylate
Methacrylic Acid Glycidyl Ester
2-((Methacryloxy)methyl)oxirane
oxiran-2-ylmethyl methacrylate
EINECS 203-441-9
Glycidyl methacrylate(GMA)
MFCD00005137
2,3-epoxypropyl methacrylate
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
189.0 at 760 mmHg
[ Melting Point ]:
-52°C
[ Molecular Formula ]:
C7H10O3
[ Molecular Weight ]:
142.152
[ Flash Point ]:
76.1
[ Exact Mass ]:
142.062988
[ PSA ]:
38.83000
[ LogP ]:
1.39
[ Vapour Pressure ]:
0.6±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.458
[ Storage condition ]:
Refrigerator
[ Stability ]:
Unstable. Light sensitive. May be stabilized with around 100ppm MEHQ. Refrigerate.
[ Water Solubility ]:
0.5-1.0 g/100 mL at 20 ºC
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OZ4375000
- CHEMICAL NAME :
- Methacrylic acid, 2,3-epoxypropyl ester
- CAS REGISTRY NUMBER :
- 106-91-2
- BEILSTEIN REFERENCE NO. :
- 0002506
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 26
- MOLECULAR FORMULA :
- C7-H10-O3
- MOLECULAR WEIGHT :
- 142.17
- WISWESSER LINE NOTATION :
- T3OTJ B1OVY1&U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 597 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/m3/6H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1400 mg/m3/6H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1400 mg/m3/6H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 450 uL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 697 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1400 mg/m3/6H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2100 mg/kg/30D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach Kidney, Ureter, Bladder - changes primarily in glomeruli
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 206 mg/m3/6H/26W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Endocrine - changes in spleen weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 40 ppm/6H/9D-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - deviated nasal septum Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 206 mg/m3/6H/26W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Cardiac - EKG changes not diagnostic of specified effects Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 78 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-THE NETHERLANDS:TWA 0.04 ppm (0.24 mg/m3) JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1341 No. of Facilities: 95 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 4002 (estimated)
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302 + H332-H311-H314-H317-H341-H350-H360F-H370
[ Precautionary Statements ]:
P201-P260-P280-P305 + P351 + P338-P310
[ Target Organs ]:
Respiratory Tract
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R20/21/22;R36/38;R43
[ Safety Phrases ]:
S26-S28-S28A-S45-S36/37-S53
[ RIDADR ]:
UN 2810 6.1/PG 3
[ WGK Germany ]:
2
[ RTECS ]:
OZ4375000
[ Packaging Group ]:
III
[ Hazard Class ]:
8
[ HS Code ]:
2916140000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2916140000
[ Summary ]:
2916140000. other esters of methacrylic acid. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:80.0%
Articles
J. Sep. Sci. 38 , 2938-44, (2015)
This study introduces a preparation method for polymer-encased monolith frits with improved durability for liquid chromatography columns. The inner surface of the polyether ether ketone tubing is pret...
Encapsulation of porcine pancreatic islets within an immunoprotective capsule comprising methacrylated glycol chitosan and alginate.J. Biomed. Mater. Res. B. Appl. Biomater. 103(3) , 503-18, (2015)
Encapsulation of cells in biocompatible polymer matrices represents a powerful tool for cell-based therapies and therapeutic delivery systems. This technology has successfully been used to deliver pan...
Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.J. Chromatogr. A. 1345 , 17-28, (2014)
A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) p...