PF-03246799
Names
Biological Activity
[Description]:
A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A; has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors, demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.
[References]
References 1. Andrews MD, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. 2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. View Related Products by Target 5-HT Receptor
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
418.2±33.0 °C at 760 mmHg
[ Molecular Formula ]:
C15H17N3
[ Molecular Weight ]:
239.316
[ Flash Point ]:
206.7±25.4 °C
[ Exact Mass ]:
239.142242
[ LogP ]:
1.31
[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C
[ Index of Refraction ]:
1.580