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Otophylloside B

Names

[ CAS No. ]:
106758-54-7

[ Name ]:
Otophylloside B

Biological Activity

[Description]:

Qingyangshengenin B, a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Qingyangshengenin B has antiepileptic activity[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Li JL, et al. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole. J Nat Prod. 2015 Jul 24;78(7):1548-55.

[2]. Yang J, et al. Otophylloside B Protects Against Aβ Toxicity in Caenorhabditis elegans Models of Alzheimer's Disease. Nat Prod Bioprospect. 2017 Apr;7(2):207-214.

[3]. Li X, et al. Antiepileptic C21 steroids from the roots of Cynanchum otophyllum. J Asian Nat Prod Res. 2015;17(7):724-32.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
898.5±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C49H78O16

[ Molecular Weight ]:
923.134

[ Flash Point ]:
249.0±27.8 °C

[ Exact Mass ]:
922.528992

[ LogP ]:
6.29

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.563

[ Storage condition ]:
2-8℃

Related Compounds