Ethyl carbamimidothioate hydrobromide (1:1)

Names

[ Name ]:
Ethyl carbamimidothioate hydrobromide (1:1)

[Synonym ]:
MFCD00012585
Ethiron
S-ethylisothiouronium hydrobromate
S-Ethylisothio Urea,Hydrobromide
Ethyl carbamimidothioate hydrobromide (1:1)
Ethiron bromide
USAF EL-18
S-ethylthiouronium bromide
2-Ethyl-2-isothiourea hydrobromide
S-Ethylisothiuronium bromide
S-Ethylthiuronium bromide
2-Ethyl-2-thiopseudourea hydrobromide
2-ethyl isothiourea hydrobromide
Carbamimidothioic acid, ethyl ester, hydrobromide (1:1)
Bromide S-ethylisothiuronium
etiron
S-Ethylisothiouronium hydrobromide
ethyl imidothiocarbamate hydrobromide
S-ETHYLISOTHIOUREA HYDROBROMIDE

Biological Activity

[Description]:

S-EIT (hydrobromide) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

EIT (S-ethylisothiourea) Hydrobromide 是 II 型 NOS 的选择性抑制剂。EIT 对 LPS 诱导的血浆 [NOx] 增加产生剂量依赖性和 > 95% 的抑制。EIT 的 ED50 值为 0.4 mg/kg。用 L-精氨酸（但不是 D-精氨酸）预处理可防止死亡率，同时不影响 II 型 NOS 依赖性 NO 的产生，表明毒性可能是由于抑制其他 NOS 亚型（内皮或神经元）之一 [1 ].选择性 NOS II 拮抗剂减弱但不阻断胎儿肺中剪切应力诱导的血管舒张。NOS II 活性的刺激（可能来自平滑肌细胞）在剪切应力诱导的肺血管舒张过程中部分促成了 NO 介导的 PVR（肺血管阻力）下降。在存在 AMT 或另一种选择性 iNOS 抑制剂 S-乙基异硫脲 (EIT) 的情况下用同种异体抗原刺激的脾细胞比在没有 iNOS 抑制剂的情况下刺激的细胞产生更多的白细胞介素 (IL)-4 和 IL-10。Th1 细胞因子 IL-2 和干扰素 (IFN)-γ 的产生并未因抑制 NO 合成而增强。急性给予 EIT (380 nmol/h)，另一种诱导型一氧化氮合酶选择性抑制剂，也减弱了妊娠引起的肾小球滤过率和有效肾血浆流量的增加。

Chemical & Physical Properties

[ Density]:
1.19 g/cm3

[ Boiling Point ]:
159.6ºC at 760 mmHg

[ Melting Point ]:
79-81°C

[ Molecular Formula ]:
C₃H₉BrN₂S

[ Molecular Weight ]:
185.09

[ Flash Point ]:
50.3ºC

[ Exact Mass ]:
183.966980

[ PSA ]:
75.17000

[ LogP ]:
2.39110

[ Vapour Pressure ]:
2.26mmHg at 25°C

[ Index of Refraction ]:
1.548

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UM6825000

CHEMICAL NAME :: Pseudourea, 2-ethyl-2-thio-, hydrobromide

CAS REGISTRY NUMBER :: 1071-37-0

LAST UPDATED :: 198706

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C3-H8-N2-S.Br-H

MOLECULAR WEIGHT :: 185.11

WISWESSER LINE NOTATION :: SHYZUN2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1419,1974

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S22-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UM6825000

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system.

Neoplasia 4(4) , 332-6, (2002)

A model to study the effectiveness of potential chemopreventive agents that inhibit neoplastic process by different mechanisms has been used to test the efficacy of seven nitric oxide synthase (NOS) i...

Inotropic response to endothelin-1, isoprenaline and calcium in cardiomyocytes isolated from endotoxin treated rats: effects of ethyl-isothiourea and dexamethasone.

Br. J. Pharmacol. 130(6) , 1275-82, (2000)

1. The contractile effects of endothelin-1, isoprenaline and extracellular calcium were assessed on ventricular cardiomyocytes isolated from lipopolysaccharide-treated rats. The involvement of nitric ...

Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy.

Hypertension 39(2 Pt 2) , 586-90, (2002)

Acute, nonselective nitric oxide synthase inhibition in the pregnant rat decreases glomerular filtration rate and renal plasma flow, suggesting a role for nitric oxide in mediating renal vasodilation ...