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FKGK18

Names

[ CAS No. ]:
1071001-09-6

[ Name ]:
FKGK18

[Synonym ]:
2-Hexanone, 1,1,1-trifluoro-6-(2-naphthalenyl)-
1,1,1-Trifluoro-6-(2-naphthyl)-2-hexanone

Biological Activity

[Description]:

FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM; displays 195 and >455 times more potent for GVIA iPLA(2) than for GIVA cPLA(2) and GV sPLA(2); inhibits Ca2+-independent PLA2 activity in a concentration-dependent manner, similar to S-BEL, which preferentially inhibits cytosol-associated iPLA2β; FKGK18 a valuable tool to explore the role of GVIA iPLA(2) in cells and in vivo models.

[References]

References 1. Kokotos G, et al. J Med Chem. 2010 May 13;53(9):3602-10. 2. Ali T, et al. PLoS One. 2013 Aug 20;8(8):e71748. 3. Bone RN, et al. Diabetes. 2015 Feb;64(2):541-54. 4. Dedaki C, et al. J Med Chem. 2019 Mar 12. doi: 10.1021/acs.jmedchem.8b01216. View Related Products by Target Phospholipase

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
382.5±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H15F3O

[ Molecular Weight ]:
280.285

[ Flash Point ]:
202.8±19.4 °C

[ Exact Mass ]:
280.107513

[ LogP ]:
4.80

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.528

Related Compounds