Kazusamycin B

Names

[ Name ]:
Kazusamycin B

Biological Activity

[Description]:

Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

[In Vitro]

Kazusamycin B (PD 124895; 5 ng/mL; 24 h; 1210 cells) 具有时间依赖性的细胞毒性，使细胞周期停滞在 G1 期[2]。 Kazusamycin B (5-50 ng/mL; 0-6 h; 1210 cells) 适度抑制 RNA 合成，但特异性抑制 2 小时[2]。 Cell Cycle Analysis[2] Cell Line: 1210 cells Concentration: 5 ng/mL Incubation Time: 24 h Result: Arrested cell cycle at G1 phase at 4 hours.

[References]

[1]. Funaishi K, et, al. Kazusamycin B, a novel antitumor antibiotic. J Antibiot (Tokyo). 1987 Jun;40(6):778-85.

[2]. Takamiya K, et, al. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. J Antibiot (Tokyo). 1988 Dec;41(12):1854-61.

Chemical & Physical Properties

[ Density]:
1.118g/cm3

[ Boiling Point ]:
754.2ºC at 760 mmHg

[ Molecular Formula ]:
C₃₂H₄₆O₇

[ Molecular Weight ]:
542.70

[ Flash Point ]:
236.5ºC

[ Exact Mass ]:
542.32400

[ PSA ]:
121.13000

[ LogP ]:
5.36700

[ Vapour Pressure ]:
2.96E-26mmHg at 25°C

[ Index of Refraction ]:
1.554

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OA0551000

CHEMICAL NAME :: Kazusamycin B

CAS REGISTRY NUMBER :: 107140-30-7

LAST UPDATED :: 199706

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C32-H46-O7

MOLECULAR WEIGHT :: 542.78

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 10 ng/L

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 41,1854,1988