Bromobenzene
Names
[ CAS No. ]:
108-86-1
[ Name ]:
Bromobenzene
[Synonym ]:
phenyl bromide
phenyl benzyl thioether
BENZYL PHENYL SULFIDE
benzyl-phenylsulphide
Bromobenzene
Benzene, bromo-
BROMOBENZENE FOR SYNTHESIS
BROMOBENZENE (100 ML )
Benzylthiobenzene
BROMBENZOL
EINECS 203-623-8
Phenyl benzyl sulfide
Ph-S-CH2-Ph
Monobromobenzene
BROMO-BENZENE
1-bromobenzene
MFCD00000055
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Boiling Point ]:
154.2±9.0 °C at 760 mmHg
[ Melting Point ]:
-31 °C
[ Molecular Formula ]:
C6H5Br
[ Molecular Weight ]:
157.008
[ Flash Point ]:
51.1±0.0 °C
[ Exact Mass ]:
155.957458
[ LogP ]:
2.99
[ Vapour density ]:
5.41 (vs air)
[ Vapour Pressure ]:
4.1±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.556
[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
insoluble.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CY9000000
- CHEMICAL NAME :
- Benzene, bromo-
- CAS REGISTRY NUMBER :
- 108-86-1
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 25
- MOLECULAR FORMULA :
- C6-H5-Br
- MOLECULAR WEIGHT :
- 157.02
- WISWESSER LINE NOTATION :
- ER
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2699 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20411 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3882 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 21 gm/m3/2H
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 817 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 2700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 14400 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3768 mg/kg/18D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 500 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-HUNGARY:TWA 3 mg/m3;STEL 6 mg/m3;Skin JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83863 No. of Facilities: 105 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 18936 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83863 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1891 (estimated) No. of Female Employees: 238 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS07, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H226-H315-H411
[ Precautionary Statements ]:
P273
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R10;R38;R51/53
[ Safety Phrases ]:
S61-S45-S36/37
[ RIDADR ]:
UN 2514 3/PG 3
[ WGK Germany ]:
2
[ RTECS ]:
CY9000000
[ Packaging Group ]:
III
[ Hazard Class ]:
3
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Sci. Ind. Res. 65(10) , 808, (2006)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...
The ionization mechanisms in direct and dopant-assisted atmospheric pressure photoionization and atmospheric pressure laser ionization.J. Am. Soc. Mass Spectrom. 25(11) , 1870-81, (2014)
A novel, gas-tight API interface for gas chromatography-mass spectrometry was used to study the ionization mechanism in direct and dopant-assisted atmospheric pressure photoionization (APPI) and atmos...
Ion/molecule reactions for detecting ammonia using miniature cylindrical ion trap mass spectrometers.Analyst 136(1) , 120-7, (2011)
Gaseous ammonia, a common toxic industrial compound, is not detected readily in ion trap mass spectrometers because its molecular ion falls below the low-mass cutoff (~m/z 40) normally used when exami...