4-(4-Nitrobenzyl)pyridine

Names

[ Name ]:
4-(4-Nitrobenzyl)pyridine

[Synonym ]:
4-(4-Nitrobenzyl)pyridine
Pyridine, 4-[(4-nitrophenyl)methyl]-
4-(4-Nitro-benzyl)-pyridine
4-[(4-nitrophenyl)methyl]pyridine
EINECS 214-108-2
4-(p-Nitrobenzyl)pyridine
Pyridine, 4- (p-nitrobenzyl)-
MFCD00006445

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
383.4±22.0 °C at 760 mmHg

[ Melting Point ]:
69-71 °C(lit.)

[ Molecular Formula ]:
C₁₂H₁₀N₂O₂

[ Molecular Weight ]:
214.220

[ Flash Point ]:
185.6±22.3 °C

[ Exact Mass ]:
214.074234

[ PSA ]:
58.71000

[ LogP ]:
2.44

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.609

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT6360000

CHEMICAL NAME :: Pyridine, 4-(p-nitrobenzyl)-

CAS REGISTRY NUMBER :: 1083-48-3

BEILSTEIN REFERENCE NO. :: 0170877

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H10-N2-O2

MOLECULAR WEIGHT :: 214.24

WISWESSER LINE NOTATION :: T6NJ D1R DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#12116 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - E0062 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 86 (estimated) No. of Female Employees: 78 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UT6360000

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Colorimetric assays for quantitative analysis and screening of epoxide hydrolase activity.

Biotechnol. Lett. 27(23-24) , 1921-7, (2005)

Focusing on directed evolution to tailor enzymes as usable biocatalysts for fine chemistry, we have studied in detail several colorimetric assays for quantitative analysis of epoxide hydrolase (EH) ac...

2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA) inhibits trichothecene production by Fusarium graminearum through suppression of Tri6 expression.

Int. J. Food Microbiol. 214 , 123-8, (2015)

Fusarium head blight (FHB) is a devastating disease of wheat (Triticum aestivum L.) caused by a mycotoxigenic fungus Fusarium graminearum resulting in significantly decreased yields and accumulation o...

The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity.

Proc. West. Pharmacol. Soc. 42 , 13-6, (1999)

Pyrrolizidine alkaloids (PAs) are a large group of structurally similar toxins. In animals, including man, they are hepatotoxic and in some cases pneumo- and neurotoxic. PAs are metabolized by the liv...