Propionyl coenzyme A lithium

Names

[ Name ]:
Propionyl coenzyme A lithium

[Synonym ]:
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tet rahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphor yl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl ] propanethioate,lithium

Biological Activity

[Description]:

Propionyl coenzyme A lithium, a coenzyme A derivative of propionic acid, is an important metabolic intermediate formed by the thioester bond between coenzyme A and propionic acid. The breakdown and production of Propionyl coenzyme A lithim is important for the metabolism of organisms[1][2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Propionyl coenzyme A lithium causes toxic effects due to its accumulation and the impact of its metabolism on cell wall synthesis and maintenance in Mycobacterium tuberculosis[1]. Propionyl coenzyme A lithium can be converted to β-hydroxypropionic acid via a peroxisomal enzyme-modified β-oxidation pathway in Arabidopsis[2]. Propionyl coenzyme A lithium causes the formation of propionic acidemia due to its abnormal accumulation, which often occurs in the neonatal developmental stage[3].

[References]

[1]. Ernesto J Muñoz-Elías, et al. Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Mol Microbiol. 2006 Jun;60(5):1109-22.

[2]. Kerry A Lucas, et al. Peroxisomal metabolism of propionic acid and isobutyric acid in plants. J Biol Chem. 2007 Aug 24;282(34):24980-9.

[3]. Oleg A Shchelochkov, et al. Propionic Acidemia. 2012 May 17 [updated 2016 Oct 6]. In: Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₄₀LiN₇O₁₇P₃S

[ Molecular Weight ]:
830.53800

[ Exact Mass ]:
830.15700

[ PSA ]:
425.34000

[ LogP ]:
1.33650

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P337 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism.

J. Bacteriol. 182 , 7007-7013, (2000)

The Saccharomyces cerevisiae ICL1 gene encodes isocitrate lyase, an essential enzyme for growth on ethanol and acetate. Previous studies have demonstrated that the highly homologous ICL2 gene (YPR006c...

Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases.

Environ. Microbiol. 13 , 1534-1548, (2011)

Gene duplication represents an evolutionary mechanism for expanding metabolic potential. Here we analysed the evolutionary relatedness of isocitrate and methylisocitrate lyases, which are key enzymes ...

The role of acyl-coenzyme A carboxylase complex in lipstatin biosynthesis of Streptomyces toxytricini.

Appl. Microbiol. Biotechnol. 87 , 1129-1139, (2010)

Streptomyces toxytricini produces lipstatin, a specific inhibitor of pancreatic lipase, which is derived from two fatty acid moieties with eight and 14 carbon atoms. The pccB gene locus in 10.6 kb fra...