β-Methylcrotonyl coenzyme A lithium

Names

[ Name ]:
β-Methylcrotonyl coenzyme A lithium

[Synonym ]:
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate,lithium
trans-3-Methyl-2-butenoyl Coenzyme A

Biological Activity

[Description]:

β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

β-Methylcrotonyl coenzyme A carboxylase, which is involved in amino acid metabolism, induces the activity of this enzyme in plant cells due to carbohydrate starvation and can be used as a new biochemical marker of the starvation-triggered autophagy process[1].

[References]

[1]. S Aubert, et al. Induction of beta-methylcrotonyl-coenzyme A carboxylase in higher plant cells during carbohydrate starvation: evidence for a role of MCCase in leucine catabolism. FEBS Lett. 1996 Apr 1;383(3):175-80.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₄₂LiN₇O₁₇P₃S

[ Molecular Weight ]:
856.57600

[ Exact Mass ]:
856.17300

[ PSA ]:
425.34000

[ LogP ]:
1.89270

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Regulation of [beta]-Methylcrotonyl-Coenzyme A Carboxylase Activity by Biotinylation of the Apoenzyme.

Plant Physiol. 108 , 1133-1139, (1995)

Regulation of the expression of the gene(s) coding for the 78-kD, biotin-containing subunit of [beta]-methylcrotonyl-coenzyme A carboxylase (MCCase) was investigated in different organs of tomato (Lyc...

Induction of beta-methylcrotonyl-coenzyme A carboxylase in higher plant cells during carbohydrate starvation: evidence for a role of MCCase in leucine catabolism.

FEBS Lett. 383 , 175-180, (1996)

Induction of beta-methylcrotonyl-coenzyme A carboxylase (MCCase) activity was observed during carbohydrate starvation in sycamore cells. In mitochondria isolated from starved cells, we noticed a marke...

Essential arginine residues in the active sites of propionyl CoA carboxylase and beta-methylcrotonyl CoA carboxylase.

Enzyme 24 , 302-306, (1979)

At least one arginine residue is essential for substrate binding in or near the active sites of propionyl CoA carboxylase (PCC) and beta-methylcrotonyl CoA carboxylase (beta MCC) in cultured human fib...