2-Hydrazinoethanol

Names

[ CAS No. ]:
109-84-2

[ Name ]:
2-Hydrazinoethanol

[Synonym ]:
(β-Hydroxyethyl)hydrazine
2-hydrazinylethanol
β-Hydroxyethylhydrazine
MFCD00007623
β-Hydroxyethyl hydrazine
EINECS 203-711-6
2-Hydrazinoethanol
Ethanol, 2-hydrazinyl-
2-Hydroxyethylhydrazine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
248.9±0.0 °C at 760 mmHg

[ Melting Point ]:
−70 °C(lit.)

[ Molecular Formula ]:
C₂H₈N₂O

[ Molecular Weight ]:
76.098

[ Flash Point ]:
73.9±0.0 °C

[ Exact Mass ]:
76.063660

[ PSA ]:
58.28000

[ LogP ]:
-1.68

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.470

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL2800000

CHEMICAL NAME :: Ethanol, 2-hydrazino-

CAS REGISTRY NUMBER :: 109-84-2

BEILSTEIN REFERENCE NO. :: 1731669

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C2-H8-N2-O

MOLECULAR WEIGHT :: 76.12

WISWESSER LINE NOTATION :: ZM2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 139 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 572 mg/kg/78W-I-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 78,177,1980

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H315-H319-H335-H351

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23/24/25;R36/37/38;R40

[ Safety Phrases ]:
S23-S26-S36/37/39-S45

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
KL2800000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

X-ray Single Crystal Structure, DFT Calculations and Biological Activity of 2-(3-Methyl-5-(pyridin-2'-yl)-1H-pyrazol-1-yl) Ethanol.

Molecules 21(8) , doi:10.3390/molecules21081020, (2016)

A pyridylpyrazole bearing a hydroxyethyl substituent group has been synthesized by condensation of (Z)-4-hydroxy-4-(pyridin-2-yl)but-3-en-2-one with 2-hydroxyethylhydrazine. The compound was well char...

Divergent mechanisms of suicide inactivation for ethanolamine ammonia-lyase.

J. Am. Chem. Soc. 127(24) , 8856-64, (2005)

Ab initio molecular orbital calculations have been used to study the mechanism of suicide inactivation of ethanolamine ammonia-lyase induced by three different substrate analogues. Analysis of the nor...

Use of pig hepatocytes to study the inhibition of monoamine oxidase by furazolidone.

Food Chem. Toxicol. 29(3) , 185-91, (1991)

Primary cultures of pig hepatocytes were used to examine the irreversible inhibition of monoamine oxidase (MAO), which has been observed in tissues of a number of different animal species after oral t...