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(3R,4S)-Tofacitinib

Names

[ CAS No. ]:
1092578-46-5

[ Name ]:
(3R,4S)-Tofacitinib

[Synonym ]:
(3R,4S)-Tofacitinib|
CS-1109
1-Piperidinepropanenitrile,4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)--oxo-,(3R,4S)
3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile
3-((3R,4S)-3-((1H-Indol-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropan-enitrile
(3R,4S)-Tofacitinib

Biological Activity

[Description]:

(3R,4S)-Tofacitinib is an enantiomer of Tofacitinib. Tofacitinib inhibits JAK3 with IC50 of 1 nM.

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[Related Small Molecules]

Baricitinib | Upadacitinib | Pacritinib | CYT387 | AZD1480 | Fedratinib(SAR302503,TG101348) | WP1066 | CHZ868 | AT9283 | GLPG0634 | Itacitinib | cerdulatinib | LY2784544 | SB1317 | Peficitinib

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
585.8±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H20N6O

[ Molecular Weight ]:
312.370

[ Flash Point ]:
308.1±30.1 °C

[ Exact Mass ]:
312.169861

[ PSA ]:
88.91000

[ LogP ]:
0.93

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.646

[ Storage condition ]:
-20°C

Related Compounds