(16α)-16,17-Epoxypregn-4-ene-3,20-dione

Names

[ Name ]:
(16α)-16,17-Epoxypregn-4-ene-3,20-dione

[Synonym ]:
Pregn-4-ene-3,20-dione, 16,17-epoxy-, (16α)-
16α,17α-Epoxyprogesterone
16α,17α-Epoxy-4-pregnen-3,20-dione
EINECS 214-147-5
pregn-4-ene-3,20-dione, 16,17-epoxy-, (16α,17α)-
ZK-5197
MFCD00055948
(16α,17α)-16,17-Epoxypregn-4-ene-3,20-dione
16,17-EPOXYPROGESTERONE
16,17a-Epoxyprogesterone
(16α)-16,17-Epoxypregn-4-ene-3,20-dione
16Alpha,17Alpha-Epoxyprogesterone
16a,17a-Epoxyprogest
EPOXY PROGESTERONE
W-oxide
16a,17a-Epoxy-4-Pregnen-3,20-Dione
16alpha,17-Epoxyprogesterone
16A,17A-EPOXY PROGESTERONE
Pregn-4-ene-3,20-dione, 16-α,17-epoxy-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
466.9±45.0 °C at 760 mmHg

[ Melting Point ]:
128 to 132ºC

[ Molecular Formula ]:
C₂₁H₂₈O₃

[ Molecular Weight ]:
328.445

[ Flash Point ]:
204.4±28.8 °C

[ Exact Mass ]:
328.203857

[ PSA ]:
46.67000

[ LogP ]:
2.73

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.569

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5022000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 16-alpha,17-epoxy-

CAS REGISTRY NUMBER :: 1097-51-4

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H28-O3

MOLECULAR WEIGHT :: 328.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TU5022000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Biosynthesis and metabolism of 16 alpha, 17-epoxy-C21-steroids in rat liver microsomes.

J. Steroid Biochem. 13(10) , 1181-205, (1980)