4-Acetylpyridine

Names

[ Name ]:
4-Acetylpyridine

[Synonym ]:
1-pyridin-4-ylethanone
Ethanone, 1- (4-pyridinyl)-
T6NJ DV1
1-(pyridin-4-yl)ethanone
4-Acetylpyridine
1-(Pyridin-4-yl)ethanon
Methyl 4-pyridyl ketone
EINECS 214-350-9
1-(4-Pyridinyl)ethanone
Ethanone, 1-(4-pyridinyl)-
MFCD00006433

Biological Activity

[Description]:

4-Acetylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

[In Vitro]

4-乙酰基吡啶与-和 4-甲酰基吡啶（H3FoPyS、H4FoPyS）反应生成缩氨基脲。乙酰吡啶与噻吩-2-甲醛反应得到2-氯-6-乙氧基-4-β-(2-噻吩基)丙烯酰基吡啶，其在哌啶作为催化剂存在下在回流乙醇中与丙二腈反应得到氰氨基吡喃衍生物。

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
212.8±13.0 °C at 760 mmHg

[ Melting Point ]:
13-16 °C(lit.)

[ Molecular Formula ]:
C₇H₇NO

[ Molecular Weight ]:
121.14

[ Flash Point ]:
87.0±27.3 °C

[ Exact Mass ]:
121.052765

[ PSA ]:
29.96000

[ LogP ]:
0.24

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.514

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB5426000

CHEMICAL NAME :: Ketone, methyl 4-pyridyl

CAS REGISTRY NUMBER :: 1122-54-9

BEILSTEIN REFERENCE NO. :: 0107629

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H7-N-O

MOLECULAR WEIGHT :: 121.15

WISWESSER LINE NOTATION :: T6NJ DV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 6200 ppm

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 163,23,1986

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OB5426000

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Toward prediction of alkane/water partition coefficients.

J. Med. Chem. 51 , 3720-30, (2008)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the pa...

The B vitamins nicotinamide (B3) and riboflavin (B2) stimulate metamorphosis in larvae of the deposit-feeding polychaete Capitella teleta: implications for a sensory ligand-gated ion channel.

PLoS ONE 9(11) , e109535, (2014)

Marine sediments can contain B vitamins, presumably incorporated from settled, decaying phytoplankton and microorganisms associated with decomposition. Because B vitamins may be advantageous for the e...

Cyanoacetic acid hydrazones of 3-(and 4-)acetylpyridine and some derived ring systems as potential antitumor and anti-HCV agents.

Arch. Pharm. (Weinheim) 339(1) , 14-23, (2006)

Two new acetylpyridinehydrazones derived from cyanoacetic acid hydrazide have been synthesized namely: cyanoacetic acid (1-pyridin-3 or 4-yl-ethylidene) hydrazides (1a,b). and some derived ring system...