UCN-01
Names
Chemical & Physical Properties
[ Density]:
1.63g/cm3
[ Boiling Point ]:
705.7ºC at 760mmHg
[ Molecular Formula ]:
C28H26N4O4
[ Molecular Weight ]:
482.53000
[ Flash Point ]:
380.6ºC
[ Exact Mass ]:
482.19500
[ PSA ]:
89.68000
[ LogP ]:
4.56460
[ Vapour Pressure ]:
6.64E-21mmHg at 25°C
[ Index of Refraction ]:
1.827
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KC6600010
- CAS REGISTRY NUMBER :
- 112953-11-4
- LAST UPDATED :
- 199312
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C28-H26-N4-O4
- MOLECULAR WEIGHT :
- 482.58
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 42,571,1989
Safety Information
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
KC6600010
Articles
BMC Cancer 15 , 17, (2015)
DNAX accessory molecule-1 (DNAM-1) is an activating receptor constitutively expressed by macrophages/dendritic cells and by T lymphocytes and Natural Killer (NK) cells, having an important role in ant...
Induction of DNA damage and G2 cell cycle arrest by diepoxybutane through the activation of the Chk1-dependent pathway in mouse germ cells.Chem. Res. Toxicol. 28(3) , 518-31, (2015)
1,2:3,4-Diepoxybutane (DEB) is a major carcinogenic metabolite of 1,3-butadiene (BD), which has been shown to cause DNA strand breaks in cells through its potential genotoxicity. The adverse effect of...
The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.Autophagy 11 , 1373-88, (2015)
Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy....