ALW-II-49-7

ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2); displays excellent overall kinase selectivity against a panel of over 350 kinases; decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.

References 1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96. 2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. View Related Products by Target Discoidin Domain Receptor (DDR)