2,3-Dehydro-3,4-dihydro ivermectin

Names

[ Name ]:
2,3-Dehydro-3,4-dihydro ivermectin

Biological Activity

[Description]:

2,3-Dehydro-3,4-dihydro ivermectin is an analog of ivermectin (HY-15310) and an anthelmintic. 2,3-Dehydro-3,4-dihydro ivermectin has activity against L. amazonensis promastigotes and amastigotes (IC50s=13.8 and 3.6 µM, respectively) without inducing cytotoxicity to macrophages (IC50= 65.5 µM).

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₈H₇₄O₁₄

[ Molecular Weight ]:
875.09300

[ Exact Mass ]:
874.50800

[ PSA ]:
170.06000

[ LogP ]:
5.60140

Related Compounds

2-[3-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)PROPYL]-1H-ISOINDOLE-1,3(2H)-DIONE
2-(3-hydroxy-3,4-dihydro-1H-isochromen-1-yl)acetaldehyde
2,3-dimethyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
2-(3-methylbut-2-enyl)-3,4-dihydro-1H-isoquinoline
2-[[3-(1-benzofuran-2-yl)-3,4-dihydro-2H-pyrrol-5-yl]amino]ethanol
2,3,4,6-tetrahydro-1,6-benzothiazocin-5-one
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
Ethyl 5-aminopent-2-ynoate
1-Oxo-1-phenylpropan-2-yl 2-(furan-2-yl)-4-methyl-6-(methylsulfanyl)pyrimidine-5-carboxylate
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-[2-(4-methoxybenzoyl)-3-methyl-1-benzofuran-5-yl]acetamide
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
Ethyl 8-methoxy-2-methylimidazo[1,2-a]pyrazine-3-carboxylate