(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt

Names

[ Name ]:
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin trifluoroacetate salt

[Synonym ]:
OVTA
N-[(1-Sulfanylcyclohexyl)acetyl]-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-3-thioxo-L-alanyl-L-prolyl-L-ornithyl-O-methyl-L-tyrosinamide
L-Tyrosinamide, N-[2-(1-mercaptocyclohexyl)acetyl]-L-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-3-thioxo-L-alanyl-L-prolyl-L-ornithyl-O-methyl-
Ota-vasotocin

Biological Activity

[Description]:

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor

Research Areas >> Neurological Disease

[Target]

Oxytocin[1]

[In Vivo]

(d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (50-1000 ng; Intra-MPOA; 1 μL) 抑制大鼠雄性性行为的某些方面[1]。 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin (100 ng; i.c.v.; 1 μL) 可有效抑制雄性大鼠交配行为后的痛觉减退[2]。 Animal Model: Adult Long–Evans/Blue-Spruce rats[1] Dosage: 50 ng, 200 ng, and 1 μg Administration: Intra-MPOA (medial preoptic area) injection, 1 μL Result: Significantly increased intromission latency and anogenital investigation at 1 μg dose. Significantly decreased intromission ratio (2) at all doses. Animal Model: Adult male and female Long-Evans rats (8 weeks old, 220–260 g BW)[2] Dosage: 100 ng Administration: Intracerebroventricular injection, 1 μL Result: Was effective in reducing pain threshold heightened by copulatory behavior.

[References]

[1]. Gil M, et al. Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat. Horm Behav. 2011 Apr;59(4):435-43.

[2]. Futagami H, et al. Oxytocin mediates copulation-induced hypoalgesia of male rats. Neurosci Lett. 2016 Apr 8;618:122-126.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₅₄H₇₉N₁₁O₁₃S₂

[ Molecular Weight ]:
1154.401

[ Exact Mass ]:
1153.530029

[ PSA ]:
483.20000

[ LogP ]:
3.80

[ Index of Refraction ]:
1.633