NAN-190 hydrobromide

Names

[ Name ]:
NAN-190 hydrobromide

[Synonym ]:
1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide
1-[2-METHOXYPHENYL]-4-[4-(2-PHTHALIMIDO)-BUTYL]PIPERAZINE HYDROCHLORIDE
NAN-190 HYDROCHLORIDE
NAN-190 HYDROBROMIDE
NAN-190 (hydrobromide)

Biological Activity

[Description]:

NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.Target: 5-HT in vitro: NAN-190 is a 5-HT1A antagonist. [3] NAN-190 is a selective antagonist of 5-HT1A. [1]in vivo: NAN-190 (0.5 mg/kg, ip), as a 5-HT1A receptor antagonist, is injected concomitantly with the effective dose of fluoxetine. NAN-190 (5-HT1A receptor antagonist) reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats. [2]

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

Research Areas >> Neurological Disease

[References]

[1]. Shahane SA, et al. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen. 2014 Jan;19(1):66-76.

[2]. Sharifi H, et al. Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors. Adv Pharm Bull. 2013;3(1):203-6.

[3]. Citó MC, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015 Jan;48(1):57-64.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
560.8ºC at 760mmHg

[ Molecular Formula ]:
C₂₃H₂₈BrN₃O₃

[ Molecular Weight ]:
474.39100

[ Flash Point ]:
293ºC

[ Exact Mass ]:
473.13100

[ PSA ]:
53.09000

[ LogP ]:
3.79250

[ Vapour Pressure ]:
1.32E-12mmHg at 25°C

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%