Benzenesulfonamide,4-amino-N-2-pyrazinyl-
Names
[ CAS No. ]:
116-44-9
[ Name ]:
Benzenesulfonamide,4-amino-N-2-pyrazinyl-
[Synonym ]:
SULFAPYRAZINE
4-amino-N-pyrazin-2-yl-benzenesulfonamide
2-Sulfanilamidopyrazine
sulfanilic acid pyrazin-2-ylamide
N(sup 1)-2-Pyrazinylsulfonilamide
Sulfanilamide,N1-(pyrazinyl)
Benzenesulfonamide,4-amino-N-pyrazinyl
Sulfanilsaeure-pyrazin-2-ylamid
Pyrazine,sulfanilamido
N1-2-Pyrazinylsulfanilamide
4-amino-N-2-pyrazinylbenzenesulfonamide
4-amino-N-pyrazinyl-benzenesulfonamide
Chemical & Physical Properties
[ Density]:
1.496g/cm3
[ Boiling Point ]:
485.5ºC at 760mmHg
[ Molecular Formula ]:
C10H10N4O2S
[ Molecular Weight ]:
250.27700
[ Flash Point ]:
247.4ºC
[ Exact Mass ]:
250.05200
[ PSA ]:
106.35000
[ LogP ]:
2.59460
[ Vapour Pressure ]:
1.41E-09mmHg at 25°C
[ Index of Refraction ]:
1.679
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DA9550000
- CHEMICAL NAME :
- Benzenesulfonamide, 4-amino-N-pyrazinyl-
- CAS REGISTRY NUMBER :
- 116-44-9
- BEILSTEIN REFERENCE NO. :
- 0235481
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H10-N4-O2-S
- MOLECULAR WEIGHT :
- 250.30
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 45600 mg/kg/22W-C
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Endocrine - thyroid weight (goiter) Related to Chronic Data - death
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 45 gm/kg/90D-C
- TOXIC EFFECTS :
- Liver - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 79,354,1943
Safety Information
[ HS Code ]:
2935009090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2935009090
[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%