Ozoralizumab

Names

[ Name ]:
Ozoralizumab

Biological Activity

[Description]:

Ozoralizumab (ATN-103) is an anti-TNFα humanized antibody. Ozoralizumab is a humanized trivalent nanobody compound that consists of two anti-human TNFα nanobodies and an anti-human serum albumin (HSA) nanobody. Ozoralizumab can be used in research of arthritis[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

[In Vitro]

Ozoralizumab (ATN-103; 0-1000 pM; 48 h) 在 L929 细胞细胞毒性试验中具有高 TNFα 中和效力，对人 TNFα 和猴 TNFα 的 KD 值分别为 20.2 pM 和 16.1 pM[1]。

[In Vivo]

Ozoralizumab (ATN-103; 1 mg/kg; s.c.; Tg197 人 TNF 转基因小鼠) 抑制关节炎并降低关节炎评分[1]。 Animal Model: Tg197 human TNF transgenic mice[1] Dosage: 1 mg/kg Administration: Subcutaneous injection Result: Reduced the mean histopathologic score in the Tg197 mice. Had ability to neutralize TNFα activity.

[References]

[1]. Ishiwatari-Ogata C, et, al. Ozoralizumab, a Humanized Anti-TNFα NANOBODY® Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG. Front Immunol. 2022 Feb 22;13:853008.

Chemical & Physical Properties

No Any Chemical & Physical Properties